January 2023 Featured Editorial Board Member

Ryuichiro Akagi, MD, PhD
Director of Knee Surgery and Sports Medicine Center
Oyumino Central Hospital
Chiba, Japan

Dr. Akagi is a board-certified Orthopaedic Surgeon specializing in knee surgery at Oyumino Central Hospital (Chiba, Japan). He is currently the director of the Knee Surgery and Sports Medicine Center. He serves as the head team physician for the Japanese Beach Soccer national team and Altiri Chiba (professional basketball). In addition, he was previously the head team physician for the Blue Thunders (American football).

He is a specialist in knee surgery, taking care of patients of all ages and performing any procedures, including arthroscopic surgeries, osteotomies, and arthroplasties, with an emphasis on cartilage regeneration procedures. He currently presides over a multicenter research project on the region’s clinical outcome after autologous chondrocyte implantation. Dr. Akagi graduated from the School of Medicine of Chiba University in 2004. After his residency in general Orthopaedics, he started his career as a knee surgeon in 2009 at Chiba University Hospital under Prof. Takahisa Sasho. After completing the doctoral program at the Graduate School of Medicine of Chiba University in 2013, he engaged in basic research on gene expression in cartilage under Prof. Martin Lotz at the Scripps Research Institute (San Diego, California). From 2015 to March 2022, he served as assistant professor of the knee surgery division at Chiba University Hospital. He started his career at Oyumino Central Hospital in April 2022. In 2015, he completed the program of International Olympic Committee Diploma in Sports Medicine and served at the polyclinic in the athlete’s village during the 2020 Tokyo Olympic and Paralympic Games. He was elected as a traveling fellow for the ESSKA-APKASS traveling fellowship program in 2018 (Godfather: Prof. Denny Lie from Singapore).

Selected Published Work

Akagi R, Saisu T, Segawa Y, Sasho T, Moriya H, Takahashi K, Kamegaya M. Natural history of popliteal cysts in the pediatric population. J Pediatr Orthop 2013 Apr-May;33(3):262-8

Akagi R, Sasho T, Saito M, Endo J, Yamaguchi S, Muramatsu Y, Mukoyama S, Akatsu Y, Katsuragi J, Fukawa T, Takahashi K. Effective knock down of Matrix Metalloprotainase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model. J Orthop Res 2014 Sep;32:1175-80, Epub 2014 May 22

Endo J, Watanabe A, Sasho T, Yamaguchi S, Saito M, Akagi R, Muramatsu Y, Mukoyama S, Katsuragi J, Akatsu Y, Fukawa T, Okubo T, Osone F, Takahashi K. Utility of T2 mapping and dGEMRIC for evaluation of cartilage repair after allograft chondrocyte implantation in a rabbit model. Osteoarthritis Cartilage 2015 Feb;23(2):280-8, Epub 2014 Nov 6

Akatsu Y, Yamaguchi S, Mukoyama S, Morikawa T, Yamaguchi T, Tsuchiya K, Iwasaki J, Akagi R, Muramatsu Y, Katsuragi J, Fukawa T, Endo J, Takahashi K, Sasho T. Accuracy of high resolution ultrasound in the detection of meniscal tears and determination of the visible area of menisci. J Bone Joint Surg Am 2015 May 20;97:799-806, Epub 2015 Jul 16

Alvarez-Garcia O, Fisch KM, Wineinger NE, Akagi R, Saito M, Sasho T, Su AI, Lotz MK. Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage. Arthritis Rheumatol 2016 Aug;68:1876-86

Akagi R, Akatsu Y, Fisch KM, Alvarez-Garcia O, Teramura T, Muramatsu Y, Saito M, Sasho T, Su AI, Lotz MK. Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes. Osteoarthritis Cartilage 2017 Jun;25(6):943-51, Epub 2016 Nov 22

Hoshi H, Akagi R, Yamaguchi S, Muramatsu Y, Akatsu Y, Yamamoto Y, Sasaki T, Takahashi K, Sasho T. Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice. Cell Tissue Res 2017 May;368(2):379-87, Epub 2017 Jan 24

Akatsu Y, Akagi R, Fukawa T, Yamaguchi S, Sasho T. Ultrasound for treating meniscocapsular separation together with arthroscopy. Arthrosc Tech. 2016 Dec 19;5(6), eCollection 2016 Dec

Sato Y, Akagi R, Akatsu Y, Matsuura Y, Takahashi S, Yamaguchi S, Enomoto T, Nakagawa R, Hoshi H, Sasaki T, Kimura S, Ogawa Y, Sadamasu A, Ohtori S, Sasho T. The effect of femoral bone tunnel configuration on tendon-bone healing in an anterior cruciate ligament reconstruction: An animal study. Bone Joint Res. 7(5):327-35, 2018

Enomoto T, Akagi R, Ogawa Y, Yamaguchi S, Hoshi H, Sasaki T, Sato Y, Nakagawa R, Kimura S, Ohtori S, Sasho T. Timing of intra-articular injection of synovial mesenchymal stem cells affects cartilage restoration in a partial thickness cartilage defect model in rats. Cartilage. 2020 Jan;11(1):122-9, Epub 2018 Jul 10

Nakagawa R, Akagi R, Yamaguchi S, Enomoto T, Sato Y, Kimura S, Ogawa Y, Sadamasu A, Ohtori S, Sasho T. Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model. Connect Tissue Res. 2019 Jul;60(4):335-43, Epub 2018 Oct 26

Akagi R, Muramatsu Y, Mukoyama S, Sugiyama H, Yamaguchi S, Ohtori S, Sasho T. Arthroscopic reduction and internal fixation of posterior cruciate ligament avulsion fracture using an adjustable length loop device. Arthrosc Tech. 2020 Dec 21;9(12), eCollection 2020 Dec

Ogura T, Asai S, Akagi R, Fukuda H, Yamaura I, Sakai H, Ichino Y, Takahashi T, Omodani T, Saito C, Ninomiya T, Shiko Y, Tsuchiya A, Takahashi K, Sasho T. Joint effusion at 6 months is a significant predictor of joint effusion 1 year after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2021 Nov;29(11):3839-3845, Epub 2021 Jan 21

Takeda T, Akagi R, Sato Y, Enomoto T, Nakagawa R, Kimura S, Yamaguchi S, Nishikawa S, Sasho T. Multiple osteochondritis dissecans in multiple joints. Case Rep Orthop. 2021 Jan 28;eCollection

Watanabe S, Akagi R, Shiko Y, Ono Y, Kawasaki Y, Ohdera T, Ohtori S, Sasho T. Intra- and Inter-observer reliability of implant positioning evaluation on a CT-based three-dimensional postoperative matching system for total knee arthroplasty. BMC Musculoskelet Disord. 2021 Apr 17;22(1):363

Ono Y, Akagi R, Mikami Y, Shinohara M, Hosokawa H, Horii M, Watanabe S, Ogawa Y, Sadamasu A, Kimura S, Yamaguchi S, Ohtori S, Sasho T. Effect of systemic administration of granulocyte colony-stimulating factor on a chronic partial-thickness cartilage defect in a rabbit knee joint. Cartilage. 2021 Dec;13(2_suppl):175S-184S

Watanabe S, Akagi R, Ninomiya T, Yamashita T, Tahara M, Kimura S, Ono Y, Yamaguchi S, Ohtori S, Sasho T. Comparison of joint awareness after medial unicompartmental knee arthroplasty and high tibial osteotomy: a retrospective multicenter study. Arch Orthop Trauma Surg. 2022 Jun;142(6):1133-1140, Epub 2021 Jul 16

Toyoshima Y, Akagi R, Nabeshima K. Isometric exercise during immobilization reduces the time to return to play after lateral ankle sprain. Phys Ther Sport. 2021 Nov;52:168-172

Horii M, Akagi R, Ogawa Y, Yamaguchi S, Kimura S, Ono Y, Watanabe S, Shinohara M, Hosokawa H, Ohtori S, Sasho T. Foot morphology and correlation with lower extremity pain in Japanese children: A cross-sectional study of the foot posture index-6. J Orthop Sci. 2021 Oct 26;Online ahead of print

Horii M, Akagi R, Takahashi S, Watanabe S, Ogawa Y, Kimura S, Yamaguchi S, Ohtori S, Sasho T. Risk factors for the occurrence and protraction of patellar and patellar tendon pain in children and adolescents: a prospective cohort study of 3 years. BMC Musculoskelet Disord. 2022 Apr 26;23(1):389, 2022

Minamoto Y, Akagi R, Maki S, Shiko Y, Tozawa R, Kimura S, Yamaguchi S, Kawasaki Y, Ohtori S, Sasho T. Automated detection of anterior cruciate ligament tears using a deep convolutional neural network. BMC Musculoskelet Disord. 2022 Jun 15;23(1):577, 2022

Hozumi T, Akagi R, Fabricant PD, Teratani T, Kimura S, Yamaguchi S, Ohtori S. Cross-cultural adaptation and validation of the Japanese version of the Hospital for Special Surgery Functional Activity Brief Scale (HSS Pedi-FABS). Orhop J Sports Med. 2022 May accepted

Shinohara M, Akagi R, Watanabe A, Kato Y, Sato Y, Morikawa T, Iwasaki J, Nakagawa K, Akatsu Y, Ohtori S, Sasho T. Time-dependent change in cartilage repair tissue evaluated by magnetic resonance imaging up to 2 years after atelocollagen-assisted autologous cartilage transplantation: data from the CaTCh study. Cartilage. 2022 May accepted

Horii M, Akagi R, Kimura S, Watanabe S, Yamaguchi S, Sasho T, Ohtori S. The influence of COVID-19 pandemic on the incidence of knee pain and physical activity level in children and adolescents in Japan: a prospective observation study. J Orthop Sci. 2022 June accepted

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