Paul W. Ackermann, MD
Karolinska University Hospital
Dr. Paul W. Ackermann is a Senior Lecturer at Karolinska Institutet, and orthopaedic surgeon at the Department of Orthopaedics and Trauma, Karolinska University Hospital, both in Stockholm, Sweden. His passion for sports and particularly basketball and soccer led him to get involved with sports injuries, and this was the reason to enter a residency in orthopaedics. His mentor, Professor Per AFH Renström, a well-respected figure in orthopaedic sports medicine, introduced him to the world of sports medicine.
The mission of Dr. Ackermann’s research is to understand and exploit neurovascular pathways in the musculoskeletal system for restoring joint function, alleviating pain, and minimizing complications.
Dr. Ackermann’s research has demonstrated that patients with Achilles tendon ruptures exhibit a high risk, 50%, of suffering deep venous thrombosis. Even a silent deep venous thrombosis has by Dr. Ackermann’s research group been demonstrated to affect the patients´ outcome at one year after the rupture.
One means to facilitate the development of improved treatment of tendon injuries pursued by Dr. Ackermann’s research group is to develop biomarkers for early healing, which can predict long-term outcome. Currently Dr. Ackermann holds a grant from the Swedish Research Council to examine the effects of Intermittent Pneumatic Compression (IPC) on tissue repair and prevention of deep venous thrombosis during lower limb immobilization.
Selected Published Work
Svedman S, Juthberg R, Edman G, Ackermann PW. Reduced Time to Surgery Improves Patient-Reported Outcome and decreases the Risk of Adverse Events after Achilles Tendon Rupture. Am J Sports Med. 2018;46(12):2929-2934.
Ackermann PW, PhisitkulP, Pearce CJ. Achilles tendinopathy – treatment: state of the artISAKOS Journal 2018
Svedman S, Westin O, Aufwerber S, Edman G, Nilsson-Helander K, Carmont MR, Karlsson J, Ackermann PW. Longer duration of operative time enhances healing metabolites and improves patient outcome after Achilles tendon rupture surgery. Knee Surg Sports Traumatol Arthrosc. 2018;26(7):2011-2020.
Aufwerber S, Heijne A, Silbernagel KG, Ackermann PW. High plantar force loading after Achilles tendon rupture repair with early functional mobilization. Am J Sports Med. 2019;47(4):894-900.
Addevico F, Svedman S, Edman G, Ackermann PW. Pyruvate and Lactate as local Prognostic Biomarkers of Patient Outcome after Achilles Tendon Rupture. Scand J Med Sci Sports. 2019;29(10):1529-1536.
Svedman S, Edman G, Ackermann PW. Deep venous thrombosis after Achilles tendon rupture is associated with poor patient-reported outcome. Knee Surg Sports Traumatol Arthrosc. 2020;28(10):3309-3317.
Edman G, Silbernagel KG, Ackermann PW. Early mobilization does not reduce the risk of deep venous thrombosis after Achilles tendon rupture: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc. 2020;28(1):312-319.
Edman G, Silbernagel KG, Ackermann PW. Does Early Functional Mobilization Affect Long-Term Outcomes After an Achilles Tendon Rupture? A Randomized Clinical Trial. Orthop J Sports Med. 2020;8(3):2325967120906522.
Alim A, Grujic M, Ackerman PW, Kristiansson P, Blomgran P, Eliassson P, Peterson M, Pejler G. Glutamate Triggers the Expression of Functional Ionotropic and Metabotropic Glutamate Receptors in Mast Cells. Cell Mol Immunol. 2020;10.
Saarensilta A, Aufwerber S, Edman G, Ackermann PW. Achilles tendon ruptures during summer show the lowest incidence, but exhibit an increased risk of re-rupture. Knee Surg Sports Traumatol Arthrosc. 2020;28(12):3978-3986.
Capone G, Svedman S, Juthberg S, Edman G, Ackermann PW. Higher pyruvate levels after Achilles tendon rupture surgery could be used as a prognostic biomarker of an improved patient outcome. Knee Surg Sports Traumatol Arthrosc. 2020 May 6. doi: 10.1007/s00167-020-06037-x.
Aufwerber S, Heijne A, Edman G, Grävare Silbernagel K, Ackermann PW. Changes in tendon elongation and muscle atrophy over time after Achilles tendon rupture repair: A prospective cohort on the effects of early functional mobilization. Am J Sports Med. 2020;48(13):3296-3305.
Norimasa Nakamura, MD, PhD
Professor, Institute for Medical Science in Sports, Osaka Health Science University
Invited Professor, Global Center for Medical Engineering and Informatics, Osaka University
Dr. Norimasa Nakamura is the professor at the Institute for Medical Science in Sports at Osaka Health Science University, and the global center for the medical engineering and informatics at Osaka University. He is also guest professor at Department of Orthopaedic Surgery, Hokkaido University Medical School and Faculty of Sports Science, Beijing University, China.
He is an orthopedic surgeon at the Osaka University Hospital, specializing in arthroscopic surgery and joint preservation surgery. He received his MD at the Osaka University in 1988 and completed the residency program at Osaka University and then started PhD course. He received PhD degree at post-graduate school of Medicine, Osaka University. His thesis was the mechanism of cytoskeletal reorganization associated with integrin receptors. Hereafter he was appointed as an assistant professor, Department of Orthopaedic Surgery, Osaka University, where he engaged in arthroscopic reconstruction surgeries. Along with his clinical practice, he started a gene therapy research project to accelerate ligament healing. In 1996, he started post-doctoral research fellowship on gene therapy in ligament healing at the University of Calgary, Canada, under Prof. Cy Frank. In 1999, he was back to Osaka University and got further specialty training at Osaka Rosai Hospital. In 2009, he moved to the current position. He also serves as the Guest Professor, Department of Orthpaedic Surgery, Hokkaido University Graduate School of Medicine and Department of Orthopaedic Sports Medicine, Peking University, China. His current interest in research is joint tissue repair with main focus on the regeneration of musculoskeletal tissues using biological approaches.
Prof. Nakamura received several national and international awards amongst others Research Excellence Award (JOA), London Life Award for Medical Research (Canada), New Investigator Recognition Award (ORS), Albert Trillat Young Investigator’s Award (ISAKOS), The best paper award (JOSSM), First Prize Research Grant Award (ACL study group), Best Rated Abstract Award (ICRS).
Prof. Nakamura is an established member of many domestic and international academic societies. Specifically, he has been actively involved in ICRS (Executive board, 2010-2018 and served as the President from 2015 to 16), and ISAKOS (Board of directors from 2009 to 13, the chair of the scientific committee, 2013 to 2015, the chair of the publication committee, 2019~, and Journal of ISAKOS, Board of Trustees, 2020~).
He serves as active Editorial Board member of AJSM, Cartilage, JISAKOS, JEO and JOS. He is also active reviewer of many scientific journal amongst others JBJS, AJSM, KSSTA, Cartilage, Osteoarthritis Cartilage, Biomaterials, Acta Biomateria, Stem Cells Translational Medicine. He has authored and co-authored of international peer-reviewed articles and book chapters. He is regularly invited by international conferences as a speaker and instructor.
Selected Published Work
Bannuru RR, Osani MC, Vaysbrot EE, Arden N, Bennell K, Bierma-Zeinstra SMA, Kraus VB, Lohmander LS, Abbott JH, Bhandari M, Blanco F, Espinosa R, Haugen IK, Lin, J, Mandl LA, Moilanen E, Nakamura N, Snyder-Mackler L, Trojian T, Underwood M, McAlindon TE. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage 2019 Jul 3. pii: S1063-4584(19)31116-1.
Yokota N, Hattori M, Ohtsuru T, Otsuji M, Lyman S, Shimomura K, Nakamura N. Comparative clinical outcomes after intra-articular injection with adipose-derived cultured stem cells (ASC) or non-cultured stromal vascular fraction (SVF) for the treatment of knee osteoarthritis. Am J Sports Med 2019;47(11):2577-2583.
O’Keefe RJ, Tuan RS, Lane NE, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Fortier LA, Guldberg RE, Little DG, Marshall MF, Mao JJ, Nakamura N, Robey PG, Rosen V, Rowe DW, Schwarz EM. American Society for Bone and Mineral Research-Orthopaedic Researcg Society Joint Task Force Report on Cell Based Therapies. J Bone Miner Res. 2019 Sep 23. doi: 10.1002/jbmr.3839.
Shimomura K, Rothrauff BB, Hart DA, Hamamoto S, Kobayashi M, Yoshikawa H, Tuan RS, Nakamura N. Enhanced Repair of Meniscal Hoop Structure Injuries Using An Aligned Electrospun Nanofibrous Scaffold Combined with a Mesenchymal Stem Cell-derived Tissue Engineered Construct. Biomaterials. 2019;192:346-354.
Shimomura K, Yasui Y, Koizumi K, Chijimatsu R, Hart DA, Yonetani Y, Ando W, Nishii T, Kanamoto T, Horibe S, Yoshikawa H, Nakamura N. First-in-human pilot study of implantation of a scaffold-free tissue-engineered construct generated from autologous synovial mesenchymal stem cells for repair of knee chondral lesions. Am J Sports Med. 2018;46(10):2384-2393.
Yasui Y., Hart DA., Sugiya N., Chijimatsu R., Koizumi K., Ando W., Morigushi Y., Shimomura K., Myoi A., Yoshikawa H., Nakamura N. Time-dependent Recovery of Human Synovial Membrane MSC Function after High Dose Steroid Therapy: Case Report and Laboratory Study. Am J Sports Med. 2018;46(3):695-701.
Yamada Y, Toritsuka Y, Nakamura N, Horibe S, Sugamoto K, Yoshikawa H, Shino K. Correlation of 3D Shift and 3D Tilt of the Patella in Patients With Recurrent Dislocation of the Patella and Healthy Volunteers: An In Vivo Analysis Based on 3-Dimensional Computer Models. Am J Sports Med. 2017;45(13):3111-3118.
Chijimatsu R., Ikeya M., Yasui Y., Ikeda Y., Ebina K., Moriguchi Y., Shimomura K, Hart D.A., Yoshikawa H., Nakamura N. Characterization of mesenchymal stem cell-like cells derived from human iPSCs via neural crest development, and their application for osteochondral repair. Stem Cells Int. 2017, 2017:1960965.
Shimomura K., Moriguchi Y., Nansai R., Fujie H., Ando W., Horibe S., Hart D. A., Gobbi A., Yoshikawa H., and Nakamura N. Comparison of 2 Different Formulations of Artificial Bone for a Hybrid Implant With a Tissue-Engineered Construct Derived From Synovial Mesenchymal Stem Cells: A Study Using a Rabbit Osteochondral Defect Model. Am J Sports Med. 2017;45(3): 666-675.
Koizumi K, Ebina K, Hart DA, Hirao M, Noguchi T, Sugita N, Yasui Y, Chijimatsu R, Yoshikawa H, Nakamura N. Synovial mesenchymal stem cells from osteo- or rheumatoid arthritis joints exhibit good potential for cartilage repair using a scaffold-free tissue engineering approach. Osteoarthritis Cartilage. 2016;24:1413-1422.
Moriguchi Y, Tateishi K, Ando W, Shimonura K, Yonetani Y, Tanaka Y, Kita K, Hart D. A., Gobbi A, Shino K, Yoshikawa H, Nakamura N. Repair of meniscal lesions using a scaffold-free tissue-engineered construct derived from allogenic synovial MSCs in a miniature swine model. Biomaterials. 2013;34(9):2185-2193.
Shimomura K, Ando W, Tateishi K, Nansai R, Fujie H, Hart DA, Kohda H, Kita K, Kanamoto T, Mae T, Nakata K, Shino K, Yoshikawa H, Nakamura N. The influence of skeletal maturity on allogenic synovial mesenchymal stem cell-based repair of cartilage in a large animal model. Biomaterials. 2010;31(31):8004-8011. Ando W, Tateishi K, Hart DA, Katakai D, Tanaka Y, Nakata K, Hashimoto J, Fujie H, Shino K, Yoshikawa H, Nakamura N. Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells. Biomaterials. 2007;28(36):5462-5470.