Bruce Beynnon, MSME, PhD
Professor & Director of Research, Department of Orthopaedics and Rehabilitation, University of Vermont
Dr. Beynnon is the McClure Professor of Musculoskeletal Research at the University of Vermont College of Medicine. He received his Undergraduate, Masters, and Doctorate degrees in Mechanical Engineering from the University of Vermont and then joined the Department of Orthopaedics and Rehabilitation in 1991. Currently, Dr. Beynnon is a Full Professor and the Director of Research in the Department of Orthopaedics and Rehabilitation. He has served on the American Orthopaedic Society of Sports Medicine’s research committee, as a regular member of National Institutes of Health study sections (Geriatrics and Rehabilitation Medicine, and Skeletal Biology Structure and Regeneration Study Section) and is currently the Associate Editor of the Journal of Orthopaedic Research. His research has been supported by NIH (R01, R21, and T32 awards), The Arthritis Foundation, and other extramural sources over the last 25 years. His research has focused on the epidemiology, treatment and prevention of musculoskeletal trauma (knee, ankle, hip shoulder joints). He has laboratory, clinical, and translational research expertise in the following areas: evaluation of muscle function in advanced stage knee osteoarthritis patients; reconstruction and rehabilitation of ACL injuries; measurement of knee and ligament biomechanics in-vivo, markers of cartilage metabolism following ACL trauma and during the early progression of post traumatic osteoarthritis; and prognostic studies designed to identify the risk factors associated with severe ankle and knee ligament trauma.
His current research is focused on investigation of early skeletal muscle strength losses following knee injury and surgical reconstruction as a risk factor for progression of post-traumatic knee OA, evaluating muscle function in advanced stage knee OA patients, identification of biomarkers of cartilage metabolism and the progression of post-traumatic osteoarthritis following ACL injury/reconstruction, and prognostic studies designed to identify the risk factors for ACL trauma. He has received several research awards including the Kappa Delta Award given by the AAOS, and the NCAA, O’Donoghue, and Hughston Awards.
Selected Published Work
Wasilko SM, Tourville TW, DeSarno MJ, Slauterbeck JR, Johnson RJ, Struglics A, Beynnon BD. The relationship between synovial fluid biomarkers of articular cartilage metabolism and the patients’ perspective of outcome depends on the severity of articular cartilage damage following ACL trauma. J Orthop Res. 2015, Oct 24. PMID 26497486
Tourville TW, Poynter ME, DeSarno MJ, Struglics A, Beynnon BD. Relationship between synovial fluid ARCS-aggrecan fragments, cytokines, MMPs and TIMPs following acute ACL injury: a cross-sectional study. J Orthop Res. 2015;33(12):1796-803. PMID 26123869
Callahan DM, Tourville TW, Miller MS, Hackett SB, Cruickshank NC, Slauterbeck JR, Savage PD, Ades PA, Maughan DW, Beynnon BD, Toth MJ. Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function. Am J Physio Cell Physiol. 2015;308(11):C932-43. PMID 25810256
Callahan DM, Tourville TW, Slauterbeck JR, Ades PA, Stevens-Lapsley J, Beynnon BD, Toth MJ. Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsic muscle contractile deficits. Exp Gerontol. 2015;72:16-21. PMID: 26343257
Sturnick DR, Vacek PM, DeSarno MJ, Gardner-Morse MG, Tourville TW, Slauterbeck JR, Johnson RJ, Shultz SJ, Beynnon BD. Combined anatomic factors predicting risk of anterior cruciate ligament injury for males and females. Am J Sports Med. 2015;43(4):839-47
Beynnon BD, Vacek PM, Newell MK, Tourville TW, Smith HC, Shultz SJ, Slauterbeck JR, Johnson RJ. The effects of level of competition, sport, and sex on the incidence of first-time noncontact anterior cruciate ligament injury. Am J Sports Med. 2014;42(8):1806-1812. PMID:25016012
Argentieri EC, Sturnick DR, DeSarno MJ, Gardner-Morse MG, Slauterbeck JR, Johnson RJ, Beynnon BD. Changes to the articular cartilage thickness profile on the tibia following anterior cruciate ligament injury in athletes. Osteoarthritis and Cartilage. 2014;22(10):1453-60. PMID:2527805
Beynnon BD, Hall JS, Sturnick DR, DeSarno MJ, Gardner-Morse M, Tourville TW, Smith HC, Slauterbeck JR, Shultz SJ, Johnson RJ, Vacek PM. Increased slope of the lateral tibial plateau subchondral bone is associated with greater risk of noncontact ACL injury in females but not in males: a prospective cohort study with a nested, matched case-control analysis. Am J Sports Med. 2014;42(5):1038-48. PMID 24590006
Callahan DM, Miller MS, Sweeny AP, Tourville TW, Slauterbeck JR, Savage PD, Maugan DW, Ades PA, Beynnon BD, Toth MJ. Muscle disuse alters skeletal muscle contractile function at the molecular and cellular levels in older adult humans in a sex-specific manner. J Physiol. 2014;592(PT20):4555-73.PMID 25038243
Tourville TW, Jarrell KM, Naud S, Slauterbeck JR, Johnson RJ, Beynnon BD. Relationship between isokinetic strength and tibiofemoral joint space width changes after anterior cruciate ligament reconstruction. Am J Sports Med. 2014;42(2):302-11. PMID 24375860
Sturnick DR, Van Gorder R, Vacek PM, DeSarno MJ, Gardner-Morse MG, Tourville TW, Slauterbeck JR, Johnson RJ, Shultz SJ, Beynnon BD. Tibial articular cartilage and meniscus geometries combine to influence female risk of anterior cruciate ligament injury. J Orthop Res. 2014;32(11):1487-94. PMID: 25099246
Sturnick DR, Argentieri EC, Vacek PM, DeSarno MJ, Gardner-Morse MG, Tourville TW, Slauterbeck JR, Johnson RJ, Shultz SJ, Beynnon BD. A decreased volume of the medial tibial spine is associated with an increased risk of suffering an anterior cruciate ligament injury for males but not females. J Orthop Res. 2014;32(11):1451-7.
Beynnon BD, Vacek PM, Sturnick DR, Holterman LA, Gardner-Morse M, Tourville TW, Smith HC, Slauterbeck JR, Johnson RJ, Shultz SJ. Geometric profile of the tibial plateau cartilage surface is associated with the risk of non-contact anterior cruciate ligament injury. J Orthop Res. 2014;32(1):61-8. PMID: 24123281
Tourville TW, Johnson RJ, Slauterbeck JR, Naud S, Beynnon BD. Assessment of early tibiofemoral joint space width changes after anterior cruciate ligament injury and reconstruction: a matched case-control study. Am J Sports Med. 2013;41(4):769-78. PMID 23460333
Tourville TW, Johnson RJ, Slauterbeck JR, Naud S, Beynnon B. Relationship between markers of type II collagen metabolism and tibiofemoral joint space width changes after ACL injury and reconstruction. Am J Sports Med. 2013;41(4):779-87. PMID 23423314
Beynnon BD, Johnson RJ, Naud S, Fleming BC, Abate JA, Brattbakk B, Nichols CE. Accelerated Versus Nonaccelerated Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Prospective, Randomized, Double-Blind Investigation Evaluating Knee Joint Laxity Using Roentgen Stereophotogrammetric Analysis. Am J Sports Med 2011. 39(12):256-48. PMID:21952714
Dr. Chih-Hwa Chen, MD, MBA
Professor, Department of Orthopaedic Surgery, Taipei Medical University Hospital
Dean and Professor, College of Biomedical Engineering Taipei Medical University
Dr. Chen is a Professor in the Department of Orthopaedic Surgery, Taipei Medical University Hospital. He is served as Dean and Professor on the College of Biomedical Engineering at the Taipei Medical University in Taipei, Taiwan.
He completed his Orthopaedic Residency at Chang Gung Memorial Hospital in 1983 and did a Sports Medicine Clinical Fellowship and Research Fellowship at the University of Pittsburgh Medical Center and Musculoskeletal Research Center from 1995 to 1996.
Dr. Chen is a clinical orthopedist and surgeon-scientist who has been working in the field of sport medicine and arthroscopy. Dr. Chen’s research interests are primarily in bone and cartilage tissue engineering, biomedical material and device, and ACL healing and regeneration. He has authored one book, twenty book chapters, an educational web site, and over 100 journal articles. Dr. Chen is serving as the Editor in Chief of Journal of Orthopedic Translation (JOT), Associated Editor of Asia Pacific Sports Medicine and Rehabilitation Technique Journal (AP-SMART), and is on the Editorial Board of six other international Journals.
In 2012, he represented the Asia-Pacific Orthopaedic Society for Sports Medicine as godfather of the travelling fellows to Europe (ESSKA). He is the president of the Asia-Pacific Knee, Arthroscopy and Sports Medicine Society (APKASS).
Dr. Chen is actively involved in the international societies including AAOS, APOA, SICOT, ICRS, ESSKA, ISAKOS, ORS, AANA, FIMS, SIROT, TESi, CAOSi, TERMIS, AAC and APKASS. He has served as President of the Taiwan Arthroscopy and Knee Society (2004-2006), and as President of the Taiwan Shoulder and Elbow Society (2008-2010).
Selected Published Work
CHEN CH, Chen WJ, Shih CH: Arthroscopic posterior cruciate ligament reconstruction – Comparison of quadriceps tendon autograft and hamstring tendon autograft. Arthroscopy. 2002;18(6):603-612.
CHEN CH, Chen WJ, Shih CH, Chou SW: Arthroscopic posterior cruciate ligament reconstruction with quadriceps tendon autograft – Minimal 3 years follow-up. Am J Sport Med. 2004;32(2):361-8.
CHEN CH, Chuang TY, Wang KC, Chen WJ, Shih CH. Arthroscopic anterior cruciate ligament reconstruction with quadriceps tendon autograft – clinical outcome in 4 to 7 years. Knee Surg Sports Traumatol Arthrosc. 2006;14:1077-85.
Liu HW, CHEN CH, Tsai CL, Hsiue GH. Heterobifunctional PEG-tethered growth factor stimulated bone marrow mesenchymal stem cells differentiation and osteogenesis. Tissue engineering. 2007;13(5):1113-24.
CHEN CH, Liu HW, Tsai CL, Yu CM, Lin IH, and Hsiue GH. Photoencapsulation of bone morphogenetic protein-2 and periosteal progenitor cells improve tendon graft healing in a bone tunnel. Am J Sports Med. 2008;36(3):461-473.
CHEN CH, Chang CH, Su CI, Wang KC, Liu HT, Yu CM MD, Wong CB, Wang IC. Arthroscopic single-bundle anterior cruciate ligament reconstruction with periosteum-enveloping hamstring tendon graft, clinical outcome in 2 to 7 years. Arthroscopy. 2010;26(7):907-917.
Chuang TY, Ho WP, CHEN CH, Shieh MH, Liau JJ, Huang CH. Non-hardware posterior cruciate ligament reconstruction using knot/press-fit technique with periosteum-enveloped hamstrings tendon autograft. Am J Sports Med. 2011;39(5):1081-1089.
CHEN CH, Chang CH, Su CI, Wang KC, Liu HT, Yu CM MD, Wong CB, Wang IC. Enhancement of rotator cuff tendon-bone healing with injectable periosteum progenitor cells-BMP-2 hydrogel in vivo. Knee Surg Sports Traumatol Arthrosc. 2011;19(9):1597-1607.
Chuang TY, Ho WP, CHEN CH, Lee CH, Liau JJ, Huang CH. Arthroscopic treatment of rotator cuff tears with shoulder stiffness: a comparison of functional outcomes with and without capsular release. Am J Sports Med. 2012;40(9):2121-2127.
Lin BN, Whu SW, CHEN CH, Hsu FY, Chen JC, Liu HW, Chen CH, Liou HM. Bone marrow mesenchymal stem cells, platelet rich plasma and nanohydroxyapatite-type I collagen beads were integral parts of biomimetic bone substitutes for bone regeneration. J Tissue Eng Regen Med. 2013;7(11):841-854.
Ho WP, Lee CH, Huang CH, CHEN CH, Chuang TY. Clinical Results of Hamstring autografts in anterior cruciate ligament reconstruction: A comparison of femoral knot/press-fit fixation and Interference screw fixation. Arthroscopy. 2014;30(7):823-32.
Tang HC, Chen WC, Chiang CW, Chen LY, Chang YC, CHEN CH. Differentiation Effects of Platelet-Rich Plasma Concentrations on Synovial Fluid Mesenchymal Stem Cells from Pigs Cultivated in Alginate Complex Hydrogel. Int J Mol Sci. 2015;16:18507-21.